TORONTO – It was quarterfinal Friday at the Rogers Cup with a bevy of star-studded matchups. The day, however, started in the doubles draw with an upset.

Bob and Mike Bryan of the United States had entered this week’s tournament with their sights on a fifth Rogers Cup title and the second in as many years. But after winning their second-round match on Thursday, the top-seeded duo was ousted on Friday by the Romanian team of Florin Mergea and Horia Tecau.

While the pursuit of five Rogers Cups ends for the American brothers, the loss gives them more time to prepare for another defense; their Olympic gold medals in Rio.

Awaiting Mergea and Tecau in the semifinals will be Ivan Dodig and Marcelo Melo who defeated Henri Kontinen and John Peers 3-6, 6-4, 10-8 in their quarterfinal match on Friday.

In the singles draw, the first match of the day was between second-seeded Stan Wawrinka and South Africa’s Kevin Anderson. Anderson entered Friday’s quarter-final with a vengeance having eliminated two top seeds to get to the Round of Eight. Entering Friday’s matchup, the two had met eight times with each player winning four matches. However, a third-straight upset this week was not in the cards for the 30-year-old South African as Wawrinka dominated from start to finish, winning 6-1, 6-3 in just 73 minutes.

After bowing out in the second round of Wimbledon earlier this month, Wawrinka felt a determination to avenge that loss. He has had a solid week in Toronto thus far making a successful transition from the grass to the hard courts. Following his quarterfinal victory on Friday, the 31-year-old was asked what he had done between Wimbledon and the Rogers Cup to find his game for the hard court season.

“I took that extra time to have a bigger block,” Wawrinka said. “I had maybe four, five days off just after. Then I start big fitness preparation with a little bit tennis before coming here early to have more tennis here. I was really happy. I had some gIgreat time with my fitness coach, Pierre Paganini. Put some hard work. Was really good. I was feeling well when I arrive here.”

In the next match, No. 3 seed Kei Nishikori battled unseeded Grigor Dimitrov.

Despite his struggles in 2016, Dimitrov has had a great week in Toronto. After going the distance with Nishikori’s countryman Yuichi Sugita in the first round, he would go on to dominate the next two rounds, defeating Denis Shapovalov and Ivo Karlovic respectively. In his latter match, the Bulgarian took it to Karlovic, showing that he wasn’t intimidated by his towering 6-foot-9 frame – an asset the Croatian had used to his full advantage this week.

Against Nishikori, Dimitrov played a strong match, giving the 26-year-old all he could handle. In the end, though, the Bulgarian just didn’t have enough for the Japanese star as Nishikori won 6-3, 3-6, 6-2, improving to 3-0 in their career head-to-head.

The win puts Nishikori in Saturday’s semifinal against Wawrinka. The two will be facing each other for the fifth time with Wawrinka holding a 3-1 advantage. The last time Nishikori defeated Wawrinka was at the 2014 US Open.

Next up was No. 1-seeded Novak Djokovic who faced No. 5-seeded Tomas Berdych. Entering the match, Djokovic had won 24 out of 26 career matches against Berdych. However, If the opening set of Friday's match was any indication, it would have been difficult to have guessed that Djokovic had such a stellar record.

Berdych came out strong in this one, pushing Djokovic to a tiebreak. Unfortunately for the Czech, he just could not close out the set as the Serbian took it 7-6. Berdych attempted to regroup but Djokovic was just too much on this night, taking the decisive set 6-4 to advance to Saturday's semi-final.

Djokovic awaited the winner of the Milos Raonic and Gael Monfils match which followed. Friday marked the fifth career meeting between Canadian and Frenchman with each winning twice. The match broke the tie between the two and unfortunately for the hometown fans, it went to Monfils who won 6-4, 6-4 to advance.

En route to his previous two victories, Raonic needed just 65 and 70 minutes respectively to advance. While Friday's match lasted just 73 minutes, it was Raonic on the losing end, falling to the older, more experience Monfils. For the Frenchman, it was the second time this week that he would defeat a Canadian having eliminated Vancouver's Vasek Pospisil on Wednesday.

Djokovic and Monfils enter Saturday's match having met 12 times. Djokovic has won all 11 of those.

Friday night wasn't a total loss for Canadian fans, though, as Pospisil and partner Daniel Nestor defeated the Czech duo of Tomas Berdych and Radek Stepanek 6-3, 7-6(6) in doubles. They advance to Saturday's semifinal to face the No. 2-seeded team of Jamie Murray and Bruno Soares who defeated Raven Klaasen and Rajeev Ram (3-6, 7-5, 1-0) earlier in the day.

While the hometown crowd may not have a Canadian in the singles draw, they'll be cheering on the Canucks when they battle Murray and Soares with a spot in Sunday's final on the line.

Saturday starts off with the Romanian duo of Mergea and Tecau taking on the team of Dodig and Melo. In the singles draw, Kei Nishikori and Stan Wawrinka battle first while the other semi, Djokovic, and Monfils, wrap up the day's events.